WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:ECM-receptor interaction       ID:04512
C=85; O=22; E=1.33; R=16.51; rawP=7.06e-21; adjP=7.98e-19
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142173 NA COL6A2 collagen, type VI, alpha 2 1292 ENSG00000142173
2  ENSG00000204262 NA COL5A2 collagen, type V, alpha 2 1290 ENSG00000204262
3  ENSG00000134871 NA COL4A2 collagen, type IV, alpha 2 1284 ENSG00000134871
4  ENSG00000115414 NA FN1 fibronectin 1 2335 ENSG00000115414
5  ENSG00000188157 NA AGRN agrin 375790 ENSG00000188157
6  ENSG00000159164 NA SV2A synaptic vesicle glycoprotein 2A 9900 ENSG00000159164
7  ENSG00000108821 NA COL1A1 collagen, type I, alpha 1 1277 ENSG00000108821
8  ENSG00000081052 NA COL4A4 collagen, type IV, alpha 4 1286 ENSG00000081052
9  ENSG00000168477 NA TNXB tenascin XB 7148 ENSG00000168477
10  ENSG00000169439 NA SDC2 syndecan 2 6383 ENSG00000169439
11  ENSG00000162512 NA SDC3 syndecan 3 9672 ENSG00000162512
12  ENSG00000188153 NA COL4A5 collagen, type IV, alpha 5 1287 ENSG00000188153
13  ENSG00000169231 NA THBS3 thrombospondin 3 7059 ENSG00000169231
14  ENSG00000082781 NA ITGB5 integrin, beta 5 3693 ENSG00000082781
15  ENSG00000168542 NA COL3A1 collagen, type III, alpha 1 1281 ENSG00000168542
16  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
17  ENSG00000142156 NA COL6A1 collagen, type VI, alpha 1 1291 ENSG00000142156
18  ENSG00000130635 NA COL5A1 collagen, type V, alpha 1 1289 ENSG00000130635
19  ENSG00000187498 NA COL4A1 collagen, type IV, alpha 1 1282 ENSG00000187498
20  ENSG00000164692 NA COL1A2 collagen, type I, alpha 2 1278 ENSG00000164692
21  ENSG00000026508 NA CD44 CD44 molecule (Indian blood group) 960 ENSG00000026508
22  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664


Database:KEGG pathway       Name:Protein digestion and absorption       ID:04974
C=81; O=18; E=1.27; R=14.18; rawP=4.76e-16; adjP=2.69e-14
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142173 NA COL6A2 collagen, type VI, alpha 2 1292 ENSG00000142173
2  ENSG00000204262 NA COL5A2 collagen, type V, alpha 2 1290 ENSG00000204262
3  ENSG00000134871 NA COL4A2 collagen, type IV, alpha 2 1284 ENSG00000134871
4  ENSG00000108821 NA COL1A1 collagen, type I, alpha 1 1277 ENSG00000108821
5  ENSG00000081052 NA COL4A4 collagen, type IV, alpha 4 1286 ENSG00000081052
6  ENSG00000188153 NA COL4A5 collagen, type IV, alpha 5 1287 ENSG00000188153
7  ENSG00000187955 NA COL14A1 collagen, type XIV, alpha 1 7373 ENSG00000187955
8  ENSG00000168542 NA COL3A1 collagen, type III, alpha 1 1281 ENSG00000168542
9  ENSG00000111799 NA COL12A1 collagen, type XII, alpha 1 1303 ENSG00000111799
10  ENSG00000137509 NA PRCP prolylcarboxypeptidase (angiotensinase C) 5547 ENSG00000137509
11  ENSG00000204291 NA COL15A1 collagen, type XV, alpha 1 1306 ENSG00000204291
12  ENSG00000142156 NA COL6A1 collagen, type VI, alpha 1 1291 ENSG00000142156
13  ENSG00000130635 NA COL5A1 collagen, type V, alpha 1 1289 ENSG00000130635
14  ENSG00000101892 NA ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 23439 ENSG00000101892
15  ENSG00000187498 NA COL4A1 collagen, type IV, alpha 1 1282 ENSG00000187498
16  ENSG00000164692 NA COL1A2 collagen, type I, alpha 2 1278 ENSG00000164692
17  ENSG00000049089 NA COL9A2 collagen, type IX, alpha 2 1298 ENSG00000049089
18  ENSG00000049540 NA ELN elastin 2006 ENSG00000049540


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=21; E=3.13; R=6.70; rawP=9.36e-12; adjP=3.53e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000149269 NA PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 5058 ENSG00000149269
2  ENSG00000142173 NA COL6A2 collagen, type VI, alpha 2 1292 ENSG00000142173
3  ENSG00000204262 NA COL5A2 collagen, type V, alpha 2 1290 ENSG00000204262
4  ENSG00000134871 NA COL4A2 collagen, type IV, alpha 2 1284 ENSG00000134871
5  ENSG00000115414 NA FN1 fibronectin 1 2335 ENSG00000115414
6  ENSG00000108821 NA COL1A1 collagen, type I, alpha 1 1277 ENSG00000108821
7  ENSG00000081052 NA COL4A4 collagen, type IV, alpha 4 1286 ENSG00000081052
8  ENSG00000168477 NA TNXB tenascin XB 7148 ENSG00000168477
9  ENSG00000188153 NA COL4A5 collagen, type IV, alpha 5 1287 ENSG00000188153
10  ENSG00000169231 NA THBS3 thrombospondin 3 7059 ENSG00000169231
11  ENSG00000082781 NA ITGB5 integrin, beta 5 3693 ENSG00000082781
12  ENSG00000168542 NA COL3A1 collagen, type III, alpha 1 1281 ENSG00000168542
13  ENSG00000010810 NA FYN FYN oncogene related to SRC, FGR, YES 2534 ENSG00000010810
14  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
15  ENSG00000142156 NA COL6A1 collagen, type VI, alpha 1 1291 ENSG00000142156
16  ENSG00000130635 NA COL5A1 collagen, type V, alpha 1 1289 ENSG00000130635
17  ENSG00000170962 NA PDGFD platelet derived growth factor D 80310 ENSG00000170962
18  ENSG00000187498 NA COL4A1 collagen, type IV, alpha 1 1282 ENSG00000187498
19  ENSG00000164692 NA COL1A2 collagen, type I, alpha 2 1278 ENSG00000164692
20  ENSG00000109339 NA MAPK10 mitogen-activated protein kinase 10 5602 ENSG00000109339
21  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664


Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=14; E=1.32; R=10.63; rawP=5.47e-11; adjP=1.55e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000011465 NA DCN decorin 1634 ENSG00000011465
2  ENSG00000116985 NA BMP8B bone morphogenetic protein 8b 656 ENSG00000116985
3  ENSG00000143768 NA LEFTY2 left-right determination factor 2 7044 ENSG00000143768
4  ENSG00000115170 NA ACVR1 activin A receptor, type I 90 ENSG00000115170
5  ENSG00000156466 NA GDF6 growth differentiation factor 6 392255 ENSG00000156466
6  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
7  ENSG00000119699 NA TGFB3 transforming growth factor, beta 3 7043 ENSG00000119699
8  ENSG00000115738 NA ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3398 ENSG00000115738
9  ENSG00000055130 NA CUL1 cullin 1 8454 ENSG00000055130
10  ENSG00000090539 NA CHRD chordin 8646 ENSG00000090539
11  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
12  ENSG00000169231 NA THBS3 thrombospondin 3 7059 ENSG00000169231
13  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664
14  ENSG00000153162 NA BMP6 bone morphogenetic protein 6 654 ENSG00000153162


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=20; E=5.11; R=3.91; rawP=2.93e-07; adjP=6.62e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117425 NA PTCH2 patched 2 8643 ENSG00000117425
2  ENSG00000074047 NA GLI2 GLI family zinc finger 2 2736 ENSG00000074047
3  ENSG00000169884 NA WNT10B wingless-type MMTV integration site family, member 10B 7480 ENSG00000169884
4  ENSG00000134871 NA COL4A2 collagen, type IV, alpha 2 1284 ENSG00000134871
5  ENSG00000115414 NA FN1 fibronectin 1 2335 ENSG00000115414
6  ENSG00000081052 NA COL4A4 collagen, type IV, alpha 4 1286 ENSG00000081052
7  ENSG00000104290 NA FZD3 frizzled family receptor 3 7976 ENSG00000104290
8  ENSG00000114423 NA CBLB Cbl proto-oncogene, E3 ubiquitin protein ligase B 868 ENSG00000114423
9  ENSG00000188153 NA COL4A5 collagen, type IV, alpha 5 1287 ENSG00000188153
10  ENSG00000152284 NA TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 83439 ENSG00000152284
11  ENSG00000087245 NA MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 4313 ENSG00000087245
12  ENSG00000196730 NA DAPK1 death-associated protein kinase 1 1612 ENSG00000196730
13  ENSG00000119699 NA TGFB3 transforming growth factor, beta 3 7043 ENSG00000119699
14  ENSG00000187498 NA COL4A1 collagen, type IV, alpha 1 1282 ENSG00000187498
15  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
16  ENSG00000082512 NA TRAF5 TNF receptor-associated factor 5 7188 ENSG00000082512
17  ENSG00000109339 NA MAPK10 mitogen-activated protein kinase 10 5602 ENSG00000109339
18  ENSG00000105810 NA CDK6 cyclin-dependent kinase 6 1021 ENSG00000105810
19  ENSG00000135766 NA EGLN1 egl nine homolog 1 (C. elegans) 54583 ENSG00000135766
20  ENSG00000111087 NA GLI1 GLI family zinc finger 1 2735 ENSG00000111087


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=12; E=2.02; R=5.93; rawP=9.85e-07; adjP=1.59e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000044524 NA EPHA3 EPH receptor A3 2042 ENSG00000044524
2  ENSG00000198753 NA PLXNB3 plexin B3 5365 ENSG00000198753
3  ENSG00000149269 NA PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 5058 ENSG00000149269
4  ENSG00000182168 NA UNC5C unc-5 homolog C (C. elegans) 8633 ENSG00000182168
5  ENSG00000010810 NA FYN FYN oncogene related to SRC, FGR, YES 2534 ENSG00000010810
6  ENSG00000148948 NA LRRC4C leucine rich repeat containing 4C 57689 ENSG00000148948
7  ENSG00000133216 NA EPHB2 EPH receptor B2 2048 ENSG00000133216
8  ENSG00000169855 NA ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 6091 ENSG00000169855
9  ENSG00000184347 NA SLIT3 slit homolog 3 (Drosophila) 6586 ENSG00000184347
10  ENSG00000145147 NA SLIT2 slit homolog 2 (Drosophila) 9353 ENSG00000145147
11  ENSG00000066248 NA NGEF neuronal guanine nucleotide exchange factor 25791 ENSG00000066248
12  ENSG00000182580 NA EPHB3 EPH receptor B3 2049 ENSG00000182580


Database:KEGG pathway       Name:Amoebiasis       ID:05146
C=106; O=11; E=1.66; R=6.62; rawP=9.36e-07; adjP=1.59e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204262 NA COL5A2 collagen, type V, alpha 2 1290 ENSG00000204262
2  ENSG00000134871 NA COL4A2 collagen, type IV, alpha 2 1284 ENSG00000134871
3  ENSG00000115414 NA FN1 fibronectin 1 2335 ENSG00000115414
4  ENSG00000108821 NA COL1A1 collagen, type I, alpha 1 1277 ENSG00000108821
5  ENSG00000081052 NA COL4A4 collagen, type IV, alpha 4 1286 ENSG00000081052
6  ENSG00000130635 NA COL5A1 collagen, type V, alpha 1 1289 ENSG00000130635
7  ENSG00000119699 NA TGFB3 transforming growth factor, beta 3 7043 ENSG00000119699
8  ENSG00000188153 NA COL4A5 collagen, type IV, alpha 5 1287 ENSG00000188153
9  ENSG00000187498 NA COL4A1 collagen, type IV, alpha 1 1282 ENSG00000187498
10  ENSG00000164692 NA COL1A2 collagen, type I, alpha 2 1278 ENSG00000164692
11  ENSG00000168542 NA COL3A1 collagen, type III, alpha 1 1281 ENSG00000168542


Database:KEGG pathway       Name:Basal cell carcinoma       ID:05217
C=55; O=7; E=0.86; R=8.12; rawP=2.38e-05; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117425 NA PTCH2 patched 2 8643 ENSG00000117425
2  ENSG00000152284 NA TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 83439 ENSG00000152284
3  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
4  ENSG00000074047 NA GLI2 GLI family zinc finger 2 2736 ENSG00000074047
5  ENSG00000169884 NA WNT10B wingless-type MMTV integration site family, member 10B 7480 ENSG00000169884
6  ENSG00000104290 NA FZD3 frizzled family receptor 3 7976 ENSG00000104290
7  ENSG00000111087 NA GLI1 GLI family zinc finger 1 2735 ENSG00000111087


Database:KEGG pathway       Name:Hedgehog signaling pathway       ID:04340
C=56; O=7; E=0.88; R=7.97; rawP=2.69e-05; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117425 NA PTCH2 patched 2 8643 ENSG00000117425
2  ENSG00000116985 NA BMP8B bone morphogenetic protein 8b 656 ENSG00000116985
3  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
4  ENSG00000074047 NA GLI2 GLI family zinc finger 2 2736 ENSG00000074047
5  ENSG00000169884 NA WNT10B wingless-type MMTV integration site family, member 10B 7480 ENSG00000169884
6  ENSG00000153162 NA BMP6 bone morphogenetic protein 6 654 ENSG00000153162
7  ENSG00000111087 NA GLI1 GLI family zinc finger 1 2735 ENSG00000111087


Database:KEGG pathway       Name:Malaria       ID:05144
C=51; O=6; E=0.80; R=7.51; rawP=0.0001; adjP=0.0011
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162512 NA SDC3 syndecan 3 9672 ENSG00000162512
2  ENSG00000169231 NA THBS3 thrombospondin 3 7059 ENSG00000169231
3  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664
4  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
5  ENSG00000119699 NA TGFB3 transforming growth factor, beta 3 7043 ENSG00000119699
6  ENSG00000169439 NA SDC2 syndecan 2 6383 ENSG00000169439




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).